Understanding how cells stick together and respond to forces
Molecular mechanisms underlying force transduction at cellular adhesion complexes
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10842171
This study looks at how certain proteins help cells stick together and stay strong, which is important for healthy tissues, and it aims to understand how these proteins behave under different conditions, like during healing or in diseases like cancer and heart problems.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10842171 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular interactions at cellular adhesion complexes, specifically focusing on proteins that form adherens junctions and tight junctions. These junctions are crucial for linking neighboring cells and maintaining the integrity of epithelial tissues. The study employs advanced biophysical assays to explore how these proteins respond to mechanical forces during processes like embryonic development and tissue repair, as well as in diseases such as cancer and heart disease. By uncovering these mechanisms, the research aims to provide insights into how cells organize and remodel tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cell adhesion, including certain cancers and cardiac diseases.
Not a fit: Patients with conditions unrelated to cell adhesion mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cell adhesion, such as cancer and cardiac disorders.
How similar studies have performed: Previous research has shown promising results in understanding cellular adhesion mechanisms, indicating that this approach has potential for significant advancements.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUNN, ALEXANDER R — STANFORD UNIVERSITY
- Study coordinator: DUNN, ALEXANDER R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.