Understanding how cells shape the palate during development
Cellular mechanisms of palatal shelf outgrowth
This study is looking at how certain cells work together to form the roof of the mouth and how changes in specific genes might lead to issues like cleft palate, which can affect babies, with the hope of finding ways to better understand and prevent these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11068784 on NIH RePORTER |
What this research studies
This research investigates the cellular mechanisms involved in the development of the palate, focusing on how certain cells move and change shape to form a continuous structure. It aims to understand the roles of specific genes, Efnb1 and Shrm4, in regulating these cell behaviors during palate formation. By using advanced 3D imaging techniques and mouse genetics, the research will analyze how disruptions in these processes can lead to conditions like cleft palate, which affects many newborns. The findings could provide insights into the biological pathways that contribute to craniofacial birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cleft palate or other craniofacial anomalies.
Not a fit: Patients with craniofacial conditions unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for cleft palate and other craniofacial abnormalities.
How similar studies have performed: Previous research has shown success in understanding craniofacial development through genetic and imaging approaches, indicating that this study builds on established methods.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Shamardani, Karin — University of California, San Francisco
- Study coordinator: Shamardani, Karin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.