Understanding how cells shape the growth of teeth
Cellular Basis of Incisor Asymmetry
This study looks at how mouse teeth grow in different shapes and sizes, focusing on a special signaling pathway that helps guide this growth, which could eventually lead to better treatments for dental issues and tissue repair for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10914682 on NIH RePORTER |
What this research studies
This research investigates the cellular processes that determine the asymmetrical growth of incisor teeth during development. By studying the early stages of tooth formation in mice, the project aims to uncover how specific signaling pathways, particularly the Sonic Hedgehog (Shh) pathway, influence cell behavior and morphology. The researchers will analyze how these cellular interactions contribute to the unique shape of incisors, which could have implications for regenerative medicine and tissue repair. Patients may benefit from insights gained that could lead to new treatments for dental and tissue regeneration.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with dental anomalies or those interested in advancements in regenerative dental therapies.
Not a fit: Patients with fully developed teeth and no dental issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for dental issues and tissue regeneration.
How similar studies have performed: Previous research has shown success in understanding cellular signaling pathways in other developmental contexts, suggesting potential for breakthroughs in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Haque, Ameera Samaher — University of California, San Francisco
- Study coordinator: Haque, Ameera Samaher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.