Understanding how cells sense nutrients and regulate metabolism
Official title: Molecular Mechanisms of Organelle-based Metabolic Signaling
Funded at University of California Berkeley · NIH-11074674 · Data updated 2026-11-12
This study is looking at how a special protein in our cells helps them sense nutrients and manage energy, which could lead to better treatments for conditions like type-2 diabetes and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $614,394 |
| NIH project number | 5R35GM149302-03 |
| Project ID | NIH-11074674 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with adult-onset diabetes or metabolic disorders related to nutrient sensing.
✕Less likely to help
Patients with metabolic conditions unrelated to mTORC1 signaling may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms by which cells detect nutrients and regulate their metabolism, focusing on a key protein kinase called mTORC1. By examining how mTORC1 is activated in response to various metabolic signals, including nutrients and energy levels, the research aims to uncover insights into metabolic regulation in both healthy and diseased states. The study employs advanced techniques to explore the interactions between mTORC1 and cellular organelles, particularly lysosomes, which play a crucial role in nutrient sensing. The findings could lead to new therapeutic strategies for conditions like type-2 diabetes and cancer.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for metabolic disorders and cancers by targeting the pathways involved in nutrient sensing.
How similar studies have gone: Previous research has shown promising results in understanding mTORC1 signaling, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Zoncu, Roberto — University of California Berkeley
- Study coordinator: Zoncu, Roberto
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.