Understanding how cells sense and manage lipid levels
Lipid sensing through G protein geranylgeranylation
This study looks at how tiny worms manage fat absorption and metabolism when they don't have enough nutrients, focusing on a specific protein that helps them adapt to their energy needs, which could help us learn more about fat-related health issues for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11015760 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells regulate lipid absorption and metabolism, particularly under conditions of nutrient depletion. Using the model organism C. elegans, the study focuses on a small G protein, RAB-11.2, which plays a crucial role in sensing metabolic demands and facilitating nutrient absorption. The research aims to uncover how cells adapt their lipid synthesis in response to changing energy needs, potentially leading to new insights into metabolic health. Patients may benefit from findings that enhance understanding of lipid-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with metabolic disorders or conditions related to lipid metabolism.
Not a fit: Patients with stable metabolic conditions or those not affected by lipid metabolism issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing metabolic disorders related to lipid imbalances.
How similar studies have performed: Previous research has shown promising results in understanding lipid signaling and metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Douglas, Peter Mahan — Ut Southwestern Medical Center
- Study coordinator: Douglas, Peter Mahan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.