Understanding how cells respond to viral infections and stress
Official title: Molecular mechanisms of sensing nuclear stress and launching antiviral defense by PML
Funded at University of Connecticut Sch of Med/dnt · NIH-11097314 · Data updated 2026-11-12
This study is looking at how a protein called PML helps our cells fight off viral infections like herpes, and it aims to find ways to boost this natural defense to help people stay healthier.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $208,125 |
| NIH project number | 5R21AI178136-02 |
| Project ID | NIH-11097314 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of herpes simplex virus infections or those at risk for severe viral infections.
✕Less likely to help
Patients who do not have a history of viral infections or those with conditions unrelated to viral responses may not benefit from this research.
What this research studies
This research investigates how a specific protein, PML, helps cells defend against viral infections, particularly herpes simplex virus (HSV). It focuses on the cellular mechanisms activated by PML in response to stressors like viral infection and DNA damage. By studying how PML forms structures that trap viruses and recruit other proteins, the research aims to uncover new insights into the antiviral response of cells. This could lead to better understanding of how to enhance these defenses in patients.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating viral infections, particularly in patients with compromised immune systems.
How similar studies have gone: Previous research has shown promising results in understanding antiviral mechanisms, but this specific approach focusing on PML is relatively novel.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Bezsonova, Irina — University of Connecticut Sch of Med/dnt
- Study coordinator: Bezsonova, Irina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.