Understanding how cells respond to stress at the genetic level
Dissecting mechanisms of transcriptional regulation during stress
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11124139
This study looks at how our cells handle stress from things like aging and cancer by figuring out how they control their genes, which could help us understand how cells make important choices when times get tough.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11124139 on ClinicalTrials.gov |
What this research studies
This research investigates how mammalian cells manage gene expression when faced with environmental stresses, which can lead to serious health issues like aging and cancer. The study focuses on two key mechanisms: the formation of biomolecular condensates that regulate gene activity and the disruption of normal transcription processes. By exploring these mechanisms, the research aims to uncover the molecular basis of cellular stress responses, which could provide insights into how cells make critical decisions during stressful conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions, neurodegenerative diseases, or cancers.
Not a fit: Patients with acute stress responses unrelated to chronic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and cancers by enhancing our understanding of cellular stress responses.
How similar studies have performed: Previous research has shown promising results in understanding cellular stress responses, but this specific approach to studying gene regulation during stress is relatively novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PITCHIAYA, SETHURAMASUNDARAM — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: PITCHIAYA, SETHURAMASUNDARAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers