Understanding how cells respond to stress and regulate protein production
Official title: Translational control of stress response signaling - Equipment Supplement
Funded at New York University School of Medicine · NIH-11100708 · Data updated 2026-11-12
This study is looking at how cells handle stress and keep producing important proteins, which could help us understand diseases like Charcot-Marie-Tooth disease, and it's using fruit flies to learn more about this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $15,120 |
| NIH project number | 3R35GM148357-02S1 |
| Project ID | NIH-11100708 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Charcot-Marie-Tooth disease or other conditions related to cellular stress responses.
✕Less likely to help
Patients with conditions unrelated to cellular stress mechanisms or those not affected by Charcot-Marie-Tooth disease may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells adapt to stress through the regulation of mRNA translation. It focuses on a specific pathway known as the Integrated Stress Response (ISR), which is activated by various stressors and is crucial for cellular adaptation. By utilizing genetic tools from the fruit fly Drosophila, the study aims to uncover how certain stress-responsive genes are translated despite the general suppression of protein production during stress. This could provide insights into the cellular processes involved in diseases like Charcot-Marie-Tooth disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating metabolic and neurodegenerative diseases linked to stress response dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding stress response mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Ryoo, Hyung D — New York University School of Medicine
- Study coordinator: Ryoo, Hyung D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.