Understanding how cells respond to stress
Official title: Translational control of stress response signaling
Funded at New York University School of Medicine · NIH-10933385 · Data updated 2026-11-12
This study is looking at how cells handle stress and keep functioning properly, using fruit flies to learn more about a specific process that helps them adapt, which could help us understand diseases like Charcot-Marie-Tooth disease better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $423,750 |
| NIH project number | 5R35GM148357-02 |
| Project ID | NIH-10933385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Charcot-Marie-Tooth disease or other conditions related to stress response abnormalities.
✕Less likely to help
Patients without any metabolic or neurodegenerative diseases related to stress response mechanisms may not benefit from this research.
What this research studies
This research investigates how cells manage their response to stress by regulating the translation of messenger RNA (mRNA). It focuses on a specific pathway known as the Integrated Stress Response (ISR), which is activated by various stressors and plays a crucial role in cellular adaptation. By using genetic tools from the fruit fly Drosophila, the researchers aim to uncover how certain stress-responsive genes are translated despite the general suppression of mRNA translation during stress. This could provide insights into diseases linked to abnormal stress responses, such as Charcot-Marie-Tooth disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases associated with stress response dysregulation.
How similar studies have gone: Previous research has shown promising results in understanding stress response mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Ryoo, Hyung D — New York University School of Medicine
- Study coordinator: Ryoo, Hyung D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.