Understanding how cells respond to signals and change states
Decoding the logic of cellular signaling through the integration of dynamic, single-cell and multiplexed methods
This study is looking at how individual cells, even those that are genetically the same, react differently to signals from their environment, and it aims to help us understand how these differences happen and how cells make choices based on their unique conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10765216 on NIH RePORTER |
What this research studies
This research investigates how individual cells respond to signaling changes, focusing on the complex dynamics that can vary even among genetically identical cells. By examining the role of the AP-1 transcription factor network, the study aims to uncover how cells process signals based on their unique states, which are influenced by their epigenome. The research employs advanced techniques to analyze these cellular responses and the mechanisms that govern their diversity and adaptability. This could lead to a better understanding of how cells make decisions in response to their environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular signaling abnormalities, such as cancer or autoimmune diseases.
Not a fit: Patients with stable, non-signaling related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular behavior, potentially leading to new therapies for diseases where cell signaling is disrupted.
How similar studies have performed: Other research has shown promising results in understanding cellular signaling dynamics, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Fallahi-Sichani, Mohammad — University of Virginia
- Study coordinator: Fallahi-Sichani, Mohammad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.