Understanding how cells respond to osmotic stress using a model organism.
Regulation of stress-specific protein translation by the O-GlcNaC transferase ogt-1 and 3' mRNA processing
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10663299
This study looks at how tiny worms called C. elegans handle tough situations when their environment changes, which can help us understand how our own cells cope with stress, especially focusing on a protein called ogt-1 that helps protect them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10663299 on ClinicalTrials.gov |
What this research studies
This research investigates how cells, specifically in the nematode C. elegans, respond to osmotic stress, which is a condition that can affect human health. By studying these responses in a live animal model, the researchers aim to uncover the mechanisms that allow cells to adapt to changes in their environment, particularly focusing on the role of a specific protein called ogt-1. The study involves genetic screening to identify mutations that affect the ability to produce protective molecules during stress. This approach helps to bridge the gap between laboratory findings and real-life cellular responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to osmotic stress, such as diabetes or dehydration-related disorders.
Not a fit: Patients who do not have conditions related to osmotic stress or who are not affected by cellular stress responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular stress responses that may improve treatments for conditions like diabetes and dehydration.
How similar studies have performed: While the specific approach of using C. elegans to study osmotic stress is relatively novel, similar studies in other model organisms have shown promising results in understanding cellular stress responses.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAMITINA, SAMUEL T — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: LAMITINA, SAMUEL T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.