Understanding how cells respond to mitochondrial stress
Official title: Mechanistic Elucidation of Mitochondrial Stress Response in Human Cells
Funded at University of Connecticut Sch of Med/dnt · NIH-10940682 · Data updated 2026-11-12
This study is looking at how our cells handle stress in their energy-producing parts, called mitochondria, to find new ways to help treat health issues related to mitochondrial problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $416,250 |
| NIH project number | 1R35GM155240-01 |
| Project ID | NIH-10940682 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with degenerative neurologic disorders or conditions associated with mitochondrial dysfunction.
✕Less likely to help
Patients with non-neurological conditions or those without mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms by which human cells respond to stress in their mitochondria, which are crucial for energy production and overall cell health. The study focuses on a specific pathway that helps cells cope with mitochondrial stress, aiming to uncover how these stress responses can be manipulated for therapeutic purposes. By utilizing advanced techniques like CRISPR, the researchers will explore the signaling pathways involved in maintaining mitochondrial function and cellular fitness. This work could lead to new strategies for treating conditions related to mitochondrial dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for degenerative neurologic disorders linked to mitochondrial dysfunction.
How similar studies have gone: Other research has shown promising results in understanding mitochondrial stress responses, indicating that this approach has potential for success.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Guo, Xiaoyan — University of Connecticut Sch of Med/dnt
- Study coordinator: Guo, Xiaoyan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.