Understanding how cells respond to mild heat stress and fever
Official title: Investigating Biomolecular Condensates and Heat Shock Proteins in Cellular Responses to Sublethal Heat Shock and Fever
Funded at University of Chicago · NIH-10843079 · Data updated 2026-11-12
This study looks at how our immune cells react to mild heat stress and fever, especially as temperatures rise due to climate change, to help us better understand how these changes can affect our health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 5F30ES035279-02 |
| Project ID | NIH-10843079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing heat-related illnesses or those with conditions that affect their immune response.
✕Less likely to help
Patients who are not affected by heat-related health issues or do not have immune system concerns may not benefit from this research.
What this research studies
This research investigates how human cells, particularly immune cells, respond to mild heat stress and fever, which are increasingly relevant due to climate change and rising temperatures. The study focuses on the role of heat shock proteins and specific transcription factors in cellular responses to sublethal heat, aiming to uncover the mechanisms that regulate these responses. By examining how cells sense and adapt to these temperature changes, the research seeks to improve our understanding of heat-related health issues and their impact on human physiology.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for managing heat-related health conditions and improving immune responses during fever.
How similar studies have gone: Previous research has shown promising results in understanding cellular responses to extreme heat, but this specific focus on sublethal heat and fever is relatively novel.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Lin, Kyle Matthew — University of Chicago
- Study coordinator: Lin, Kyle Matthew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.