Understanding how cells respond to Hedgehog signals
Molecular mechanisms that regulate target cell sensitivity to Hedgehog morphogens
This study is looking at how certain genes affect how cells respond to important signals that help with tissue growth and healing, which could help us understand and treat conditions like birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11249368 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that determine how sensitive target cells are to Hedgehog morphogens, which are crucial for proper tissue development and regeneration. By using advanced techniques like genome-wide CRISPR screens, the study aims to identify specific genes that influence this sensitivity and how they affect cell signaling pathways. The goal is to uncover how changes in these mechanisms can lead to conditions such as birth defects, thereby providing insights into potential therapeutic targets for improving cell responses in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to Hedgehog signaling abnormalities, such as certain birth defects or cancers.
Not a fit: Patients with conditions unrelated to Hedgehog signaling or those who do not exhibit sensitivity to morphogen signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating birth defects and other diseases related to Hedgehog signaling.
How similar studies have performed: Previous research has shown success in understanding Hedgehog signaling pathways, but this specific focus on the regulation of target cell sensitivity is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kong, Jennifer — University of Washington
- Study coordinator: Kong, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.