Understanding how cells respond to Hedgehog signals
Molecular mechanisms that regulate target cell sensitivity to Hedgehog morphogens
This study is looking at how certain genes affect how sensitive cells are to important signals that help our tissues grow and stay healthy, which could help us understand issues like birth defects and cancer, ultimately leading to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11013302 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that determine how sensitive target cells are to Hedgehog morphogens, which are crucial for proper tissue development and maintenance. By using advanced techniques like genome-wide CRISPR screens, the study aims to identify specific genes that regulate this sensitivity. The findings could reveal how changes in signaling strength can lead to conditions such as birth defects and may provide insights into cancer biology. Patients may benefit from a better understanding of these processes, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic conditions related to Hedgehog signaling or those affected by cancers influenced by this pathway.
Not a fit: Patients with conditions unrelated to Hedgehog signaling mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to abnormal cell signaling, such as birth defects and certain cancers.
How similar studies have performed: Previous research has shown success in understanding Hedgehog signaling pathways, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kong, Jennifer — University of Washington
- Study coordinator: Kong, Jennifer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.