Understanding how cells respond to DNA replication stress
Official title: Mechanistic Characterization of the Replication Stress Response
Funded at Fred Hutchinson Cancer Center · NIH-11092833 · Data updated 2026-11-12
This study is looking at how cells fix their DNA when they’re under stress, which can help us learn more about cancer and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $440,000 |
| NIH project number | 5R35GM150532-03 |
| Project ID | NIH-11092833 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers characterized by high levels of genetic instability or those undergoing treatment that may induce replication stress.
✕Less likely to help
Patients with stable, non-cancerous conditions or those whose cancers do not exhibit replication stress may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells respond to and repair DNA damage that occurs during replication stress, a condition that can lead to mutations and genetic instability. By using advanced genetic and biochemical tools, the study aims to identify key genes involved in the replication stress response. The research involves screening multiple cell lines to uncover new insights into how cells maintain DNA integrity under stress. Patients may benefit from a better understanding of cancer biology and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved anti-cancer therapies that target the mechanisms of DNA repair and replication stress.
How similar studies have gone: Other research has shown success in understanding DNA repair mechanisms, making this approach promising but still exploring novel aspects of replication stress.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Adeyemi, Richard — Fred Hutchinson Cancer Center
- Study coordinator: Adeyemi, Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.