Understanding how cells respond to DNA replication stress
Molecular Mechanisms of Replication Stress Response
This study looks at how our cells fix problems that can happen when they copy their DNA, like when the DNA gets damaged or the copying process gets stuck, and it aims to help us understand more about diseases like cancer and aging that can arise from these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10840388 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells manage challenges during DNA replication, such as damaged DNA and stalled replication forks. It aims to uncover how cells signal for repair and stabilize replication processes to prevent harmful DNA breaks. By utilizing advanced proteomic techniques, the study analyzes the protein composition involved in these responses in human cells. The findings could lead to better understanding of diseases like cancer and aging, which are linked to failures in DNA replication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a predisposition to cancer or age-related conditions linked to DNA replication stress.
Not a fit: Patients with conditions unrelated to DNA replication stress or those not at risk for cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancer and age-related diseases by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Other research has shown promising results in understanding DNA repair mechanisms, making this approach both relevant and potentially impactful.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Dungrawala, Huzefa Mannan — University of South Florida
- Study coordinator: Dungrawala, Huzefa Mannan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.