Understanding how cells respond to DNA damage
Defining cis-regulatory networks controlling a core stress response
This study is looking at how a special protein called p53 helps cells respond when their DNA gets damaged, which is important for keeping our genes healthy, and it could help us understand more about health and diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10890139 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control how cells react to DNA damage, focusing on a key protein called p53 that plays a crucial role in maintaining the integrity of our genome. By examining how specific regulatory elements and the three-dimensional structure of DNA interact with p53, the researchers aim to uncover the pathways that determine cell fate after DNA injury. The study employs advanced genetic and biochemical techniques to explore these complex interactions, which could lead to new insights into human health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain cancers or genetic disorders affecting cell regulation.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not have a genetic predisposition to such issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for diseases related to DNA damage, including various cancers and age-related disorders.
How similar studies have performed: Previous research has shown promising results in understanding DNA damage responses, particularly involving the p53 protein, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Albany, United States
- State University of New York at Albany — Albany, United States (Active)
Researchers
- Principal investigator: Sammons, Morgan Andrew — State University of New York at Albany
- Study coordinator: Sammons, Morgan Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.