Understanding how cells respond to damage in their lysosomes
Official title: Cellular Mechanisms of Lysosomal Damage Response
Funded at University of New Mexico Health Scis Ctr · NIH-10935764 · Data updated 2026-11-12
This study looks at what happens in our cells when tiny structures called lysosomes, which help clean up waste, get damaged, and it aims to understand how this damage might be linked to diseases like cancer and brain disorders, so that we can find better ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $381,250 |
| NIH project number | 1R35GM154651-01 |
| Project ID | NIH-10935764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cancers, neurodegenerative disorders, or other conditions associated with lysosomal dysfunction.
✕Less likely to help
Patients with conditions unrelated to lysosomal function or those who do not have any of the targeted diseases may not benefit from this research.
What this research studies
This research investigates the cellular mechanisms that are activated when lysosomes, which are crucial for breaking down waste in cells, become damaged. By examining how cells respond to this damage, particularly through the formation of stress granules, the study aims to uncover important insights into various diseases, including cancer and neurodegenerative disorders. The research employs advanced molecular techniques to analyze the signaling pathways involved in these cellular responses. Patients may benefit from a deeper understanding of how lysosomal damage contributes to disease progression and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to lysosomal damage, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding cellular responses to stress, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Cassano, Jingyue Jia — University of New Mexico Health Scis Ctr
- Study coordinator: Cassano, Jingyue Jia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.