Understanding how cells reset genetic information for healthy development
Role of TET1 in germ cell reprogramming and development
This research explores how cells in the body reset their genetic instructions to ensure healthy development and prevent passing on unwanted changes to future generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11128810 on NIH RePORTER |
What this research studies
Our bodies need to carefully reset the genetic information in reproductive cells to ensure proper development and reduce the risk of passing on genetic errors. This process involves erasing certain chemical tags on DNA, a job often handled by special enzymes called TET1. We are using new mouse models and advanced sequencing tools to understand exactly how TET1 helps remove these tags and reprogram the genetic information. This work will help us learn more about how genetic information is correctly set up for new life.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation, but future applications could benefit individuals concerned with fertility, genetic inheritance, or developmental conditions.
Not a fit: Patients seeking immediate clinical treatments or direct interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work will provide fundamental knowledge about how genetic information is correctly passed down, which could eventually inform treatments for infertility or genetic disorders.
How similar studies have performed: While the specific mechanisms are still being uncovered, other studies have highlighted the importance of TET enzymes in DNA reprogramming, and this work builds upon those findings with new tools.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bartolomei, Marisa S. — University of Pennsylvania
- Study coordinator: Bartolomei, Marisa S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.