Understanding how cells replicate DNA during cell division
Genetic mechanisms of Mitotic DNA synthesis in mammalian cells
This study is looking at a new way that cells fix their DNA when they’re under stress during division, which could help us understand how both healthy and cancer cells manage to stay stable when things get tough.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10652323 on NIH RePORTER |
What this research studies
This research investigates a newly discovered process called Mitotic DNA synthesis (MiDAS), which helps cells properly segregate their chromosomes during cell division. It focuses on how this process is activated when cells experience replication stress, leading to potential issues in DNA replication. By studying the mechanisms behind MiDAS, the research aims to identify key proteins involved and how they function in both normal and cancerous cells. This could provide insights into how cells maintain stability during division, especially under stressful conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancer or those experiencing conditions that affect cell division and DNA replication.
Not a fit: Patients with stable, non-cancerous conditions that do not involve issues with cell division may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer cell behavior and potentially new therapeutic strategies to enhance the effectiveness of cancer treatments.
How similar studies have performed: Previous research has shown promising results in understanding DNA replication mechanisms, but the specific focus on MiDAS is relatively novel and untested.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Shima, Naoko — University of Minnesota
- Study coordinator: Shima, Naoko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.