Understanding how cells repair their outer membrane after damage
Official title: Role of the Septin Cytoskeleton in Plasma Membrane Repair
Funded at Ohio State University · NIH-11165132 · Data updated 2026-11-12
This study is looking at how a special protein called septin 7 helps cells fix their outer layer when it's hurt, especially after infections like Listeria, and it hopes to find new ways to help people with conditions like heart failure and muscular dystrophy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $44,015 |
| NIH project number | 1F31AI186513-01A1 |
| Project ID | NIH-11165132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from conditions like muscular dystrophy, heart failure, or chronic inflammation.
✕Less likely to help
Patients with stable, non-progressive conditions unrelated to cell membrane repair mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells repair their plasma membrane when it is damaged, particularly focusing on the role of a protein called septin 7. The study aims to understand how this protein helps cells recover from damage caused by bacterial infections, such as those from Listeria monocytogenes. By examining the cellular processes involved in membrane repair, the research seeks to uncover potential therapeutic targets for conditions related to membrane repair dysregulation, including heart failure and muscular dystrophy.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by impaired cell membrane repair, improving patient outcomes.
How similar studies have gone: Previous research has shown that understanding cellular repair mechanisms can lead to significant advancements in treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Prislusky, Mauri Isabella a. — Ohio State University
- Study coordinator: Prislusky, Mauri Isabella a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.