Understanding how cells repair DNA damage to prevent cancer
Mechanism and Regulation of Homologous Recombination in Genome Maintenance
This study is looking at how our cells fix serious DNA damage that can lead to cancer, focusing on a specific repair process and the proteins that help with it, which could lead to better cancer treatments for patients in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11136236 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA double-strand breaks, a critical type of damage that can lead to cancer if not properly fixed. The study focuses on homologous recombination, a key repair process, and explores the role of specific proteins involved in this pathway. By examining how these proteins interact and function, the research aims to uncover new insights into DNA repair processes that could inform future cancer therapies. Patients may benefit from advancements in cancer treatment strategies that arise from a better understanding of DNA repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with breast cancer or those at high risk for developing cancer due to genetic factors affecting DNA repair.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms or those who do not have a genetic predisposition to such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that enhance the effectiveness of treatments by targeting DNA repair pathways.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for significant advancements in cancer treatment.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Niu, Hengyao — Trustees of Indiana University
- Study coordinator: Niu, Hengyao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.