Understanding how cells repair DNA damage that can lead to cancer
Investigating DNA double-strand break repair mechanisms in mammalian cells
This study is looking at how our cells fix serious DNA damage that can lead to cancer, and it's especially focused on a specific repair method called microhomology-mediated end joining, which could help us find new ways to treat cancer in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11007247 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mammalian cells repair DNA double-strand breaks, a critical type of DNA damage that can lead to chromosomal rearrangements and cancer. The team uses advanced reporter systems to study different DNA repair pathways and identify new factors involved in the repair process. By focusing on microhomology-mediated end joining (MMEJ), the research aims to uncover how this repair mechanism contributes to genome instability and the development of cancer. Patients may benefit from insights gained into DNA repair processes that could inform future cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or cancers characterized by chromosomal instability.
Not a fit: Patients with conditions unrelated to DNA damage or chromosomal rearrangements may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with DNA damage.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, making this approach both relevant and promising.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wu, Xiaohua — Scripps Research Institute, the
- Study coordinator: Wu, Xiaohua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.