Understanding how cells repair DNA damage during the cell cycle
Mechanistic characterization of the cell cycle-dependent DNA repair pathway- Resubmission
This study looks at how our cells fix DNA damage and how this process is controlled during different stages of the cell cycle, which could help us find better cancer treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11034134 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA damage, focusing on how these processes are regulated throughout the cell cycle. It examines specific proteins and modifications that play crucial roles in determining which DNA repair pathway is activated when damage occurs. By studying the interactions of these proteins with chromatin, the research aims to uncover how cells maintain genomic stability, which is vital for preventing cancer. Patients may benefit from insights gained that could lead to improved cancer therapies targeting these repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to cancer, particularly those with mutations in DNA repair genes like BRCA1.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the effectiveness of anti-cancer therapies by targeting DNA repair pathways.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Leung, Justin Wai Chung — University of Texas Hlth Science Center
- Study coordinator: Leung, Justin Wai Chung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.