Understanding how cells repair DNA damage during replication
Official title: Structural and Mechanistic Studies of DNA Damage Bypass Pathways in Eukaryotes
Funded at University of Iowa · NIH-10991011 · Data updated 2026-11-12
This study is looking at how cells fix DNA damage while they’re copying themselves, which is really important for keeping our genes healthy, and it could help us find better ways to treat diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $347,926 |
| NIH project number | 5R35GM148186-03 |
| Project ID | NIH-10991011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to DNA damage or those who do not have a genetic predisposition to DNA repair issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells bypass DNA damage during replication, which is crucial for maintaining genome stability. It focuses on two specific pathways: translesion synthesis and template switching, using advanced biochemical and structural techniques. By studying how these pathways function and are regulated, the research aims to uncover fundamental insights into DNA repair processes that are vital for preventing mutations and diseases like cancer. Patients may benefit from this research as it could lead to improved understanding and treatment of conditions related to DNA damage.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of DNA repair mechanisms, potentially leading to better treatments for cancer and age-related diseases.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for significant findings.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Washington, M. Todd — University of Iowa
- Study coordinator: Washington, M. Todd
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.