Understanding how cells repair DNA damage caused by oxidative stress
Supplement to NIH Award 2 R35GM128562-06
This study is looking at how our cells fix damaged DNA, which is important for preventing cancer, and it aims to understand how different proteins work together to do this, especially in the tricky areas of our DNA, so that we can find better ways to treat cancer in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11099331 on NIH RePORTER |
What this research studies
This research investigates the base excision repair (BER) pathway, which is crucial for repairing oxidative DNA damage that can lead to cancer. The study aims to uncover how various enzymes work together in a complex to repair DNA effectively, especially within the challenging environment of chromatin. By using advanced biophysical techniques, the research seeks to clarify the mechanisms of DNA repair and how telomerase replicates telomeres, which are essential for maintaining genome stability. This knowledge could pave the way for developing new therapeutic strategies for cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers related to oxidative DNA damage or those at high risk for such conditions.
Not a fit: Patients with non-cancerous conditions unrelated to DNA damage or repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for cancer by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific approach to studying BER in chromatin is relatively novel.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Freudenthal, Bret D — University of Kansas Medical Center
- Study coordinator: Freudenthal, Bret D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.