Understanding how cells repair DNA damage caused by environmental factors
Integrative Modeling of Biomolecular Machinery in Nucleotide Excision Repair
This study is exploring how our bodies fix damaged DNA, which is important for preventing diseases like cancer and aging too quickly, and it aims to help us understand these processes better so we can find new ways to treat related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11023061 on NIH RePORTER |
What this research studies
This research focuses on the nucleotide excision repair (NER) pathway, which is crucial for maintaining the integrity of our DNA by detecting and removing harmful lesions caused by environmental toxins and radiation. By utilizing advanced computational modeling alongside experimental techniques like cryo-electron microscopy, the researchers aim to unravel the complex molecular machinery involved in this repair process. This understanding could lead to insights into various diseases associated with DNA damage, including certain cancers and accelerated aging conditions. Patients may benefit from improved knowledge of how DNA repair mechanisms work and how they can be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to DNA repair deficiencies or those affected by conditions like xeroderma pigmentosum or Cockayne syndrome.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases linked to DNA damage, such as certain cancers and aging disorders.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this integrative modeling approach is relatively novel and aims to provide deeper insights.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Ivanov, Ivaylo Nikolaev — Georgia State University
- Study coordinator: Ivanov, Ivaylo Nikolaev
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.