Understanding how cells repair DNA damage caused by certain chemicals
Replication fork dynamics and repair by Rad51 paralogs after DNA alkylation
This study is looking at how cells fix damaged DNA, focusing on a special protein complex that helps another important protein do its job, using yeast to learn more about what happens when this process goes wrong, which could help us understand similar issues in humans, especially for those at risk of cancer or with conditions like Fanconi anemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11073333 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA damage, particularly focusing on the role of a protein complex called the Shu complex in regulating another protein, Rad51, which is crucial for DNA repair. The study uses budding yeast as a model organism to explore how disruptions in this repair process can lead to cell death when exposed to alkylating agents, which are common environmental toxins. By understanding these processes, the research aims to shed light on how similar mechanisms might function in humans, especially in relation to cancer predisposition and conditions like Fanconi anemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of breast or ovarian cancer, or those diagnosed with Fanconi anemia.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms or those not affected by alkylating agents may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cancers associated with DNA repair deficiencies.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, but this specific focus on the Shu complex and its role in human cancer is relatively novel.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bernstein, Kara a — University of Pennsylvania
- Study coordinator: Bernstein, Kara a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.