Understanding how cells repair DNA damage.
Official title: Probing the mechanisms that control DNA repair pathway choice.
Funded at Johns Hopkins University · NIH-11145826 · Data updated 2026-11-12
This study is looking at how different types of cells fix their DNA when it gets damaged, which is really important for keeping our tissues healthy, and it's for anyone interested in understanding why some cells handle this better than others, especially in different stages of their development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 29, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $409,375 |
| NIH project number | 5R35GM153484-02 |
| Project ID | NIH-11145826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain cancers or degenerative disorders.
✕Less likely to help
Patients with conditions unrelated to DNA repair or those who do not have any genetic predisposition to DNA damage may not benefit from this research.
What this research studies
This research investigates the mechanisms that control how different types of cells repair DNA damage, which is crucial for maintaining healthy tissue function. By examining how factors like chromatin and nuclear RNAs influence DNA repair pathways, the research aims to uncover why certain cells respond differently to DNA damage based on their type and stage of differentiation. The approach combines advanced genomic techniques and mouse models to explore these processes in detail, potentially leading to new insights into how to improve DNA repair in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating degenerative diseases and cancers by enhancing DNA repair mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Oberdoerffer, Philipp — Johns Hopkins University
- Study coordinator: Oberdoerffer, Philipp
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.