Understanding how cells repair DNA damage
Defining DNA resection and protein localization changes that occur during DSB repair
This study is looking at how cells fix broken DNA, which can happen naturally or from damage, to help us understand better ways to edit genes and find new treatments for cancer and age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-11090353 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA double strand breaks (DSBs), which can occur due to normal cellular processes or damage. It focuses on two main repair pathways: end joining and homology directed repair, and aims to identify the factors that influence a cell's choice between these pathways. By developing a comprehensive model of DSB repair, the research seeks to enhance our understanding of DNA repair processes, which could lead to improved gene editing techniques and new strategies for diagnosing and treating conditions like cancer and age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA repair, such as certain types of cancer or age-related disorders.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for cancer and other diseases related to DNA repair deficiencies.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant advancements.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Richardson, Chris — University of California Santa Barbara
- Study coordinator: Richardson, Chris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.