Understanding how cells repair DNA damage
Official title: Dissecting the DNA Damage Response with Functional Proteomics
Funded at University of Texas Hlth Science Center · NIH-11011169 · Data updated 2026-11-12
This study is looking at how our cells fix damaged DNA and how certain proteins help with this process, which is really important for keeping us healthy and preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | January 22, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $408,179 |
| NIH project number | 1R35GM156189-01 |
| Project ID | NIH-11011169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of breast or ovarian cancer, particularly those with mutations in the BRCA1 gene.
✕Less likely to help
Patients without any known genetic predisposition to DNA damage-related conditions or those not affected by cancer may not receive direct benefits from this research.
What this research studies
This research investigates the DNA damage response (DDR), focusing on how proteins involved in DNA repair are modified and regulated. Using advanced mass spectrometry techniques, the study aims to identify new proteins and interactions that play a role in the DDR. By examining how specific kinases and phosphatases affect these processes, the research seeks to uncover the mechanisms that control DNA repair, which is crucial for maintaining cellular health and preventing diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing DNA repair mechanisms, potentially benefiting patients with cancer or genetic disorders related to DNA damage.
How similar studies have gone: Previous research has shown success in understanding DNA damage response mechanisms, but this study aims to explore novel regulatory pathways that have not been extensively tested.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Kim, Minkyu — University of Texas Hlth Science Center
- Study coordinator: Kim, Minkyu
Related research
Other NIH-funded projects on the same topics.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
Rural microvascular factors driving brain aging and dementia
This project will study how blood vessel problems in rural communities contribute to brain aging and dementia, using mobile clinics to reach people who live far from major medical centers.
-
How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
-
Gene editing therapies to prevent epileptic seizures
A new gene-editing approach aims to reduce seizures in people with epilepsy by directly modifying a brain gene tied to the condition.
-
Blocking the IL-4/13 pathway in allergic asthma and rhinoconjunctivitis to understand why treatments work differently
A high-quality clinical trial will test a targeted therapy in people with allergic asthma and allergic rhinitis to understand why symptoms and responses vary.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.