Understanding how cells repair DNA damage
Dissecting the DNA Damage Response with Functional Proteomics
This study is looking at how our cells fix damaged DNA and how certain proteins help with this process, which is really important for keeping us healthy and preventing diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11011169 on NIH RePORTER |
What this research studies
This research investigates the DNA damage response (DDR), focusing on how proteins involved in DNA repair are modified and regulated. Using advanced mass spectrometry techniques, the study aims to identify new proteins and interactions that play a role in the DDR. By examining how specific kinases and phosphatases affect these processes, the research seeks to uncover the mechanisms that control DNA repair, which is crucial for maintaining cellular health and preventing diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of breast or ovarian cancer, particularly those with mutations in the BRCA1 gene.
Not a fit: Patients without any known genetic predisposition to DNA damage-related conditions or those not affected by cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing DNA repair mechanisms, potentially benefiting patients with cancer or genetic disorders related to DNA damage.
How similar studies have performed: Previous research has shown success in understanding DNA damage response mechanisms, but this study aims to explore novel regulatory pathways that have not been extensively tested.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Kim, Minkyu — University of Texas Hlth Science Center
- Study coordinator: Kim, Minkyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.