Understanding how cells repair DNA damage
Official title: Novel Mechanisms and Regulation of Mammalian Double-Strand Break Repair
Funded at Thomas Jefferson University · NIH-11005312 · Data updated 2026-11-12
This study looks at how cells fix serious damage to their DNA, which can happen from stress or harmful substances, to help us understand how this repair process affects cancer cells and could lead to better treatments for patients with certain types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $667,775 |
| NIH project number | 5R35GM152198-02 |
| Project ID | NIH-11005312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that exhibit deficiencies in DNA repair pathways.
✕Less likely to help
Patients with cancers that do not involve DNA repair deficiencies may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells repair double-strand breaks in DNA, which can occur due to stress or exposure to harmful agents. It focuses on various DNA damage response pathways, including both error-prone and accurate repair methods. By exploring these pathways, the research aims to enhance our understanding of how DNA repair contributes to cancer cell survival and genome integrity. Patients may benefit from insights gained that could lead to new treatments for cancers associated with DNA repair deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer therapies that target specific DNA repair mechanisms.
How similar studies have gone: Previous research has successfully identified critical DNA repair mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Pomerantz, Richard T — Thomas Jefferson University
- Study coordinator: Pomerantz, Richard T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.