Understanding how cells repair DNA damage
Official title: Mechanistic Insights into Single-Strand Break Repair Within Chromatin
Funded at Case Western Reserve University · NIH-10937145 · Data updated 2026-11-12
This study is looking at how our cells fix small breaks in DNA, which happens a lot, and it’s especially for anyone interested in understanding how problems with this repair process might lead to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $402,500 |
| NIH project number | 1R35GM154859-01 |
| Project ID | NIH-10937145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain types of cancer or genetic disorders affecting DNA repair.
✕Less likely to help
Patients with conditions unrelated to DNA damage or repair mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells repair single-strand breaks in DNA, a common type of damage that occurs frequently. It focuses on the base excision repair (BER) pathway, which involves specific proteins that recognize and fix these breaks. The study will explore how poly-ADP-ribosylation and histone modifications play a role in recruiting repair proteins to the site of damage, ultimately aiming to enhance our understanding of DNA repair processes. This knowledge could provide insights into how failures in these mechanisms contribute to diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for cancer treatment by enhancing our understanding of DNA repair mechanisms.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Kim, Tae Hun — Case Western Reserve University
- Study coordinator: Kim, Tae Hun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.