Understanding how cells repair DNA damage
Structural and Mechanistic Studies of DNA Repair
This study looks at how our cells fix DNA damage caused by stress, which can lead to cancer, and it focuses on a specific repair process to understand how different proteins work together to keep our DNA healthy, with the hope of finding new ways to treat related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10919758 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair DNA damage caused by oxidative stress, a condition that can lead to cancer and other diseases. It focuses on the base excision repair (BER) pathway, which is crucial for maintaining genome stability. The study employs advanced biophysical techniques to explore how various DNA repair proteins work together in complex formations to effectively repair damaged DNA, particularly within the challenging environment of chromatin. By unraveling these processes, the research aims to provide insights that could inform the development of new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain types of cancer.
Not a fit: Patients with no history of DNA damage-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers and other diseases linked to DNA damage.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, making this approach both relevant and promising.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Freudenthal, Bret D — University of Kansas Medical Center
- Study coordinator: Freudenthal, Bret D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.