Understanding how cells repair DNA damage
Deciphering the chromatin-based DNA damage response pathway
This study is looking at how our cells fix DNA damage, which is really important for keeping us healthy, and it could help find better ways to treat diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10911067 on NIH RePORTER |
What this research studies
This research investigates the DNA damage response (DDR) pathway, which is crucial for protecting our cells from genetic damage. It aims to uncover how damaged chromatin signals the recruitment of repair proteins to fix DNA breaks, which is essential for maintaining genome integrity. The researchers will use advanced techniques such as genome editing, confocal microscopy, and quantitative mass spectrometry to explore the molecular mechanisms involved in this process. By understanding these pathways better, the research could lead to improved strategies for addressing DNA damage in various diseases, including cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to DNA damage, such as certain types of cancer or genetic disorders that affect DNA repair.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not have a genetic predisposition to DNA repair issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance DNA repair mechanisms, potentially improving treatment outcomes for patients with cancer and other genetic disorders.
How similar studies have performed: Other research has shown success in understanding DNA damage response pathways, indicating that this approach has the potential for significant advancements in the field.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Leung, Justin Wai Chung — University of Texas Hlth Science Center
- Study coordinator: Leung, Justin Wai Chung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.