Understanding how cells repair DNA damage
Official title: Core 1: Protein Biochemistry and Enzymology (PBE) Core
Funded at University of Texas Hlth Science Center · NIH-10847791 · Data updated 2026-11-12
This study looks at how our cells fix broken DNA, which is important for treating conditions like breast cancer, by focusing on two main repair methods and how a specific protein helps manage these processes.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $286,535 |
| NIH project number | 1P01CA275717-01A1 |
| Project ID | NIH-10847791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of breast cancer or those diagnosed with breast cancer, particularly those with mutations in BRCA1 or BRCA2 genes.
✕Less likely to help
Patients with conditions unrelated to DNA repair mechanisms or those not affected by breast cancer may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which cells repair DNA double-strand breaks, focusing on two main pathways: non-homologous DNA end joining (NHEJ) and homology-directed repair (HDR). The study examines how the 53BP1 protein and its associated factors regulate these repair processes, particularly during different phases of the cell cycle. By exploring the interactions between various proteins involved in DNA repair, the research aims to identify potential targets for improving treatment strategies for conditions like breast cancer. Patients may benefit from insights gained into how DNA repair mechanisms can be manipulated to enhance therapeutic outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with breast cancer and other conditions related to DNA repair deficiencies.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms, particularly in relation to breast cancer, indicating that this approach has the potential for significant advancements.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Kwon, Youngho — University of Texas Hlth Science Center
- Study coordinator: Kwon, Youngho
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.