Understanding how cells repair DNA breaks and its effects on genome stability.
Mechanisms and Genetic Consequences of Break-Induced Replication.
This study is looking at how a special way of fixing DNA breaks, called break-induced replication, works in our cells, and it hopes to find out how mistakes in this process can affect our health, which could help develop better treatments for conditions related to DNA problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10939883 on NIH RePORTER |
What this research studies
This research investigates a specific DNA repair mechanism called break-induced replication (BIR), which is crucial for maintaining genome stability in cells. By examining how BIR operates in mammalian cells, the study aims to uncover the regulatory mechanisms involved and the genetic consequences of errors that occur during this repair process. The research employs a multidisciplinary approach, integrating cell biology, biochemistry, and genomics to provide a comprehensive understanding of BIR's role in DNA repair and its implications for cell viability. Patients may benefit from insights gained about DNA repair mechanisms that could inform future therapies for conditions related to genomic instability.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic predispositions to conditions involving DNA repair deficiencies or genomic instability.
Not a fit: Patients with stable genomes and no known issues related to DNA repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for diseases associated with genomic instability, such as cancer.
How similar studies have performed: While the specific focus on BIR in mammals is relatively novel, previous research has shown success in understanding other DNA repair mechanisms, suggesting potential for impactful findings.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Min, Jaewon — Columbia University Health Sciences
- Study coordinator: Min, Jaewon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.