Understanding how cells repair damaged DNA to prevent cancer
Stalled replication fork repair in cancer predisposition and cancertherapy
This study looks at how certain genes, BRCA1 and BRCA2, help fix problems in our DNA that can lead to cancer, especially in people with a family history of breast and ovarian cancer, and it hopes to find ways to improve treatments and prevention for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10875613 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells repair stalled replication forks, which are critical for maintaining genomic stability. It focuses on the roles of BRCA1 and BRCA2 genes in this repair process, particularly in relation to hereditary breast and ovarian cancer. Using advanced tools, the research aims to quantify different types of DNA repair outcomes and understand how defects in these processes can lead to cancer predisposition. Patients may benefit from insights that could improve cancer therapies and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of breast or ovarian cancer, particularly those with known BRCA1 or BRCA2 mutations.
Not a fit: Patients without a genetic predisposition to breast or ovarian cancer or those with other unrelated cancer types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for patients at risk of hereditary breast and ovarian cancers.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, particularly in relation to BRCA1 and BRCA2, indicating that this approach builds on established findings.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Scully, Ralph — Beth Israel Deaconess Medical Center
- Study coordinator: Scully, Ralph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.