Understanding how cells repair damaged DNA sites
Function of HMCES in abasic site repair and tolerance
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-11128767
This study looks at how our cells fix certain types of DNA damage that can lead to serious health problems like cancer, focusing on a special protein called HMCES that helps protect and repair these damaged areas, with the hope that what we learn can lead to better treatments for people affected by DNA damage.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11128767 on ClinicalTrials.gov |
What this research studies
This research investigates how cells manage and repair abasic sites, which are common forms of DNA damage that can lead to serious health issues like cancer. It focuses on a specific protein, HMCES, that plays a crucial role in detecting and protecting these damaged areas in single-stranded DNA. By studying the mechanisms of this repair pathway, the research aims to uncover how cells maintain their genetic stability despite the presence of environmental toxins that can cause DNA damage. Patients may benefit from insights gained in this research that could lead to improved treatments for diseases related to DNA damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals exposed to environmental toxins or those with a family history of cancer related to DNA repair deficiencies.
Not a fit: Patients with no history of DNA damage-related conditions or those not exposed to relevant environmental factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers caused by DNA damage.
How similar studies have performed: Previous research has shown promising results in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORTEZ, DAVID K — VANDERBILT UNIVERSITY
- Study coordinator: CORTEZ, DAVID K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.