Understanding how cells repair broken DNA
DNA damage response and repair of a broken chromosome
This study looks at how cells fix serious damage to their DNA, using yeast to see how this happens, and it also explores how a bacteria related to Lyme disease changes its genes, which could help us understand similar changes in human cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project ID | NIH-11089564 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells detect and repair double-strand breaks in DNA, using budding yeast as a model organism. By inducing specific DNA damage in a controlled manner, the researchers can observe the repair processes in real-time. The study also explores how the Lyme disease bacterium, Borrelia burgdorferi, manages to alter its genetic makeup through gene conversion, which may have implications for understanding similar processes in human cancers. The findings could enhance our knowledge of DNA repair pathways and their regulation.
Who could benefit from this research
Good fit: Patients with cancers or genetic conditions related to DNA repair mechanisms may benefit from the insights gained from this research.
Not a fit: Patients with conditions unrelated to DNA damage or repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating cancers and genetic disorders linked to DNA damage.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, making this study a continuation of established scientific inquiry.
Where this research is happening
Waltham, United States
- Brandeis University — Waltham, United States (Active)
Researchers
- Principal investigator: Haber, James E — Brandeis University
- Study coordinator: Haber, James E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.