Understanding how cells repair broken DNA
Regulation of Initial Steps of Chromosomal Breaks Repair
This study is looking at how cells fix important breaks in their DNA, using fission yeast to learn more about the early steps of this repair process, which could help us understand better ways to tackle cancer and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11015039 on NIH RePORTER |
What this research studies
This research investigates the initial steps of how cells repair double-strand breaks in DNA, which are critical for maintaining genome stability. It focuses on a process called DNA end resection, which prepares the DNA for repair by loading necessary proteins. The study uses fission yeast as a model organism to explore how this process occurs in different types of chromatin, particularly in regions that are normally silent. By developing new assays, the research aims to uncover the mechanisms that control DNA repair pathways, which could have implications for understanding cancer and other diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or genetic disorders related to DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA repair or chromosomal stability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating cancers and genetic disorders caused by DNA repair deficiencies.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, but this specific approach focusing on heterochromatin is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Ira, Grzegorz a — Baylor College of Medicine
- Study coordinator: Ira, Grzegorz a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.