Understanding how cells remove unwanted structures through autophagy
Cargo-responsive mechanisms in autophagy
This study is looking at how our cells clean up harmful stuff, like damaged proteins, to help us stay healthy, especially in conditions like cancer and aging, and it's for anyone curious about how our bodies fight off problems at the cellular level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10895418 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells eliminate toxic or unwanted structures, such as damaged proteins and organelles, through a process called autophagy. By developing specific tools to study different types of cellular cargo, the research aims to uncover how various substances trigger distinct autophagy pathways. This approach involves genetic screening and advanced imaging techniques to observe how these processes work in real-time. The ultimate goal is to enhance our understanding of autophagy's role in health and disease, particularly in conditions like cancer and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to autophagy dysfunction, including certain cancers and age-related diseases.
Not a fit: Patients with conditions unrelated to autophagy or those who do not have any cellular degradation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to autophagy dysfunction, such as cancer and neurodegenerative disorders.
How similar studies have performed: Other research has shown promising results in understanding autophagy mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Shoemaker, Christopher J — Dartmouth College
- Study coordinator: Shoemaker, Christopher J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.