Understanding how cells release certain proteins that cause inflammation
Examining Molecular Regulation of Unconventional Cytoplasmic Protein Secretion
This research explores how cells release specific proteins, like those involved in inflammation, through pathways different from the usual ones.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-11145880 on NIH RePORTER |
What this research studies
Our bodies have many ways to release proteins from cells, with some well-known pathways and others that are less understood. This project focuses on these 'unconventional' ways that cells secrete proteins, especially those linked to conditions like inflammation. We are using advanced tools, including a genetic screening method and a technique to identify proteins, to discover new factors that control this process. By understanding these mechanisms, we hope to uncover new ways to manage inflammatory responses in the body.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work could benefit individuals with inflammatory conditions.
Not a fit: Patients not affected by conditions related to inflammation or protein secretion would likely not see direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to control inflammation and treat related diseases by targeting how specific proteins are released from cells.
How similar studies have performed: While the classical protein secretion pathway is well-understood, this research explores novel, unconventional secretion routes using newly developed screening methods.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Abbineni, Prabhodh Sai — Loyola University Chicago
- Study coordinator: Abbineni, Prabhodh Sai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.