Understanding how cells release and clear tiny vesicles that carry important signals.
Official title: Determining the mechanisms of extracellular vesicle release, function, and clearance
Funded at Texas A&m Agrilife Research · NIH-10765439 · Data updated 2026-11-12
This study is looking at how tiny bubbles called extracellular vesicles (EVs) are made and released by cells, using a small worm called C. elegans to help understand how these vesicles can affect other cells, which could be important for treating diseases like cancer and inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | September 5, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $367,440 |
| NIH project number | 1R35GM152234-01 |
| Project ID | NIH-10765439 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions related to inflammation or cancer may benefit from the advancements in diagnostics and treatment strategies derived from this research.
✕Less likely to help
Patients with conditions unrelated to inflammation or cancer may not find direct benefits from this research.
What this research studies
This research investigates the mechanisms by which cells release extracellular vesicles (EVs) that can influence other cells' behavior and metabolism. By using a model organism called C. elegans, the team aims to uncover the biological pathways involved in EV production and clearance. The study employs innovative imaging techniques to visualize these vesicles in real-time, which could lead to advancements in understanding their role in diseases like cancer and inflammation. The findings may also enhance the development of EVs as tools for targeted drug delivery.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and therapies that utilize extracellular vesicles for treating diseases.
How similar studies have gone: Previous research has shown promise in using extracellular vesicles for diagnostics and targeted therapies, indicating that this approach has potential for success.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Wehman, Ann M — Texas A&m Agrilife Research
- Study coordinator: Wehman, Ann M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.