Understanding how cells regulate protein diversity through splicing
Official title: Engineering cell type-specific splicing regulation
Funded at University of Washington · NIH-10934322 · Data updated 2026-11-12
This study is exploring how different types of cells manage the way genes are turned into proteins, which can help us find new ways to treat diseases by fine-tuning how genes work in specific cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $382,153 |
| NIH project number | 5R01GM149631-02 |
| Project ID | NIH-10934322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases that could benefit from targeted gene therapies.
✕Less likely to help
Patients with conditions that do not involve alternative splicing or genetic alterations may not benefit from this research.
What this research studies
This research investigates how different cell types control the process of alternative splicing, which affects the diversity of proteins produced in the body. By using advanced techniques like synthetic biology and machine learning, the team aims to create specific tools that can manipulate splicing in targeted cell types. This could lead to new ways to treat diseases by activating or silencing genes in a precise manner. The research involves creating large libraries of genetic constructs to study how splicing varies across different cell types.
Why it matters
Potential benefit: If successful, this research could lead to innovative gene therapies that are tailored to specific cell types, improving treatment outcomes for various diseases.
How similar studies have gone: Previous research has shown promise in using synthetic biology and machine learning for gene regulation, indicating a potential for success in this novel approach.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Seelig, Georg — University of Washington
- Study coordinator: Seelig, Georg
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.