Understanding how cells regulate protein degradation
Regulation of Proteasome Capacity
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-11093380
This study is looking at how tiny parts of our cells, called proteasomes, help break down damaged proteins, using a small worm called C. elegans to find out which genes affect this process, with the hope of learning more about diseases like Alzheimer's and cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11093380 on ClinicalTrials.gov |
What this research studies
This research investigates how cells control the capacity of the proteasome, a crucial component responsible for degrading damaged or unneeded proteins. By using the model organism C. elegans, the study aims to identify the genetic factors that influence proteasome function and how these factors contribute to normal cellular processes and diseases. The research employs a forward genetic approach to uncover the molecular mechanisms behind proteasome regulation, which could lead to insights into conditions like neurodegenerative diseases and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative diseases or cancers that may be linked to proteasome dysfunction.
Not a fit: Patients with conditions unrelated to proteasome function or those who do not have a genetic predisposition to the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with proteasome dysfunction, such as neurodegenerative disorders and certain cancers.
How similar studies have performed: Previous research has shown success in understanding proteasome function and its implications in various diseases, making this approach both relevant and promising.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEHRBACH, NICOLAS JOHN — FRED HUTCHINSON CANCER CENTER
- Study coordinator: LEHRBACH, NICOLAS JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancerous, Cancers