Understanding how cells regulate calcium signaling through a specific lipid.
Homeostatic Regulation of PIP2-Calcium Signaling
This study is looking at how cells keep a special fat called PIP2 in balance, which is important for helping cells respond to signals like neurotransmitters, and it focuses on a protein called Nir2 that helps move this fat to where it's needed in the cell.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11075878 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells replenish a lipid called PIP2, which is crucial for calcium signaling in response to various stimuli like neurotransmitters. The study focuses on a protein named Nir2 that helps transport phosphatidylinositol from the endoplasmic reticulum to the cell membrane, ensuring that calcium levels are properly maintained for essential cellular functions. By exploring these processes, the research aims to uncover how cells maintain homeostasis during signaling events that affect cell behavior such as secretion and migration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve disrupted calcium signaling, such as certain neurological disorders or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to calcium signaling or those who do not have any signaling pathway dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular signaling that may improve treatments for conditions related to calcium signaling dysregulation.
How similar studies have performed: Previous research has shown success in understanding calcium signaling pathways, but the specific focus on PIP2 replenishment mechanisms is relatively novel.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Liou, Jen — Ut Southwestern Medical Center
- Study coordinator: Liou, Jen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.