Understanding how cells recycle waste through a process called autophagy
Mechanisms of membrane tethering in autophagy
This study is looking at how our cells clean up and recycle their parts, especially how certain proteins help this process work better, which could be important for understanding diseases that come with aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11128705 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind autophagy, a vital cellular process that helps cells maintain balance and respond to stress by recycling cellular debris. The study focuses on the final stages of autophagy, particularly how different proteins and complexes work together to facilitate the fusion of autophagosomes with lysosomes for degradation. By using both laboratory techniques and live cell models, the research aims to uncover the protein interactions that are crucial for this recycling process, which could have implications for various aging-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing aging-related diseases or disorders, particularly those with neurodegenerative conditions.
Not a fit: Patients with acute, non-aging related conditions or those not experiencing cellular stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating neurodegenerative diseases and improving cellular health in aging populations.
How similar studies have performed: Previous research has shown promising results in understanding autophagy mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Yokom, Adam Lee — University of Missouri-Columbia
- Study coordinator: Yokom, Adam Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.