Understanding how cells recycle their nuclear components
Autophagy degradation of nuclear and chromatin constituents
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10871853
This study is looking at how our cells clean up and recycle their parts when they’re under stress, like during cancer, to help us understand how this process can keep our cells healthy and what it means for diseases like cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10871853 on ClinicalTrials.gov |
What this research studies
This research investigates the process of autophagy, specifically how cells break down and recycle their nuclear materials in response to stress, such as cancer-related changes. The study focuses on the interaction between autophagy proteins and nuclear components, exploring how these interactions lead to the degradation of nuclear lamina and other nuclear substrates. By examining these processes, the research aims to uncover new insights into the role of nuclear autophagy in maintaining cellular health and its implications for diseases, particularly cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular stress or cancer, as they may benefit from advancements in understanding nuclear autophagy.
Not a fit: Patients with conditions unrelated to cellular stress or nuclear function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to cellular stress and cancer by enhancing our understanding of nuclear autophagy.
How similar studies have performed: While autophagy has been extensively studied in cytoplasmic contexts, the exploration of nuclear autophagy is relatively novel, indicating a potential for groundbreaking findings.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOU, ZHIXUN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: DOU, ZHIXUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Genes, Cancer-Promoting Gene